English
norskBlar i forfatter "Salvesen, Øyvind"
Viser treff 1-11 av 11
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Association of Klotho protein levels and KL-VS heterozygosity with Alzheimer disease and amyloid and tau burden
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-11-22)Importance Identification of proteins and genetic factors that reduce Alzheimer disease (AD) pathology is of importance when searching for novel AD treatments. Heterozygosity of the KL-VS haplotype has been associated with reduced amyloid and tau burden. Whether this association is mediated by the Klotho protein remains unclear. Objectives To assess concentrations of Klotho in cerebrospinal ... -
Feasibility of telerehabilitation for heart failure patients inaccessible for outpatient rehabilitation
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-05-23)Aims Despite strong recommendations, outpatient cardiac rehabilitation is underused in chronic heart failure (CHF) patients. Possible barriers are frailty, accessibility, and rural living, which may be overcome by telerehabilitation. We designed a randomized, controlled trial to evaluate the feasibility of a 3-month real-time, home-based telerehabilitation, high-intensity exercise programme for ... -
Open discectomy vs microdiscectomy for lumbar disc herniation - a protocol for a pragmatic comparative effectiveness study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2016-09-02)Introduction:<br>Since the introduction of lumbar microdiscectomy in the 1970’s, many studies have attempted to compare the effectiveness of this method with that of standard open discectomy with conflicting results. This observational study is designed to compare the relative effectiveness of microdiscectomy (MD) with open discectomy (OD) for treating lumbar disc herniation, -within a large cohort, ... -
Pain During Sex Before and After Surgery for Lumbar Disc Herniation - A Multicenter Observational Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-12-15)<p>Study Design. Observational multicenter study. <p>Objective. The aim of this study was to evaluate changes in pain during sexual activity after surgery for lumbar disc herniation (LDH). <p>Summary of Background Data. There are limited data available on sexual function in patients undergoing surgery for LDH. <p>Methods. Data were retrieved from the Norwegian Registry for Spine Surgery. The ... -
Persistent Use of Prescription Opioids Before and After Lumbar Spine Surgery: Observational Study With Prospectively Collected Data From Two Norwegian National Registries
(Journal article; Tidsskriftartikkel; Peer reviewed, 2023-07-15)Study Design - Prospective pharmacoepidemiologic study.<p> <p>Objective - To investigate clinical and sociodemographic factors associated with persistent opioid use in the years following spine surgery among patients with persistent opioid use preceding lumbar spine surgery.<p> <p>Summary of Background Data - It is unknown whether successful spine surgery leads to a cessation of preoperative ... -
A prognostic model for failure and worsening after lumbar microdiscectomy: a multicenter study from the Norwegian Registry for Spine Surgery
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-10)<i>Objective</i> - To develop a prognostic model for failure and worsening 1 year after surgery for lumbar disc herniation.<br><br> <i>Methods</i> - This multicenter cohort study included 11,081 patients operated with lumbar microdiscectomy, registered at the Norwegian Registry for Spine Surgery. Follow-up was 1 year. Uni- and multivariate logistic regression analyses were used to assess potential ... -
Surgery for degenerative cervical myelopathy in patients with rheumatoid arthritis and ankylosing spondylitis: a nationwide registry-based study with patient-reported outcomes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-10-15)Purpose To compare patient-reported outcomes (PROMs) following surgery for degenerative cervical myelopathy (DCM) among patients with rheumatoid arthritis (RA) or ankylosing spondylitis (AS) versus those without rheumatic diseases. Methods Data were obtained from the Norwegian Registry for Spine Surgery. The primary outcome was change in the Neck Disability Index (NDI) at 1 year. Secondary endpoints ... -
Surgery for degenerative cervical myelopathy in the elderly: a nationwide registry-based observational study with patient-reported outcomes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2022-07-19)Background - The aim of this study was to investigate whether clinical outcomes in patients aged ≥ 70 undergoing decompressive surgery for degenerative cervical myelopathy (DCM) differ from those of younger patients (50–70 years) at 1 year.<p> <p>Methods - Data were obtained from the Norwegian Registry for Spine Surgery (NORspine). Among 651 patients included, 177 (27.2%) were ≥ 70 years old. The ... -
Surgery for Degenerative Cervical Myelopathy: A Nationwide Registry-Based Observational Study With Patient-Reported Outcomes
(Journal article; Tidsskriftartikkel; Peer reviewed, 2021-07-29)Background: Indications and optimal timing for surgical treatment of degenerative cervical myelopathy (DCM) remain unclear, and data from daily clinical practice are warranted.<p> <p>Objective: To investigate clinical outcomes following decompressive surgery for DCM. Methods: Data were obtained from the Norwegian Registry for Spine Surgery. The primary outcome was change in the neck disability index ... -
Surgery for Extraforaminal Lumbar Disc Herniation: A Single Center Comparative Observational Study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-04-13)<p><i>Background - </i>Surgery on extraforaminal lumbar disc herniation (ELDH) is a commonly performed procedure. Operating on this type of herniation is known to come with more difficulties than on the frequently seen paramedian lumbar disc herniation (PLDH). However, no comparative data are available on the effectiveness and safety of this operation. We sought out to compare clinical outcomes at ... -
Surgery for herniated lumbar disc in private vs public hospitals: A pragmatic comparative effectiveness study
(Journal article; Tidsskriftartikkel; Peer reviewed, 2020-01-04)<p><i>Background - </i>There is limited evidence on the comparative performance of private and public healthcare. Our aim was to compare outcomes following surgery for lumbar disc herniation (LDH) in private versus public hospitals. <p><i>Methods - </i>Data were obtained from the Norwegian registry for spine surgery. Primary outcome was change in Oswestry disability index (ODI) 1 year after surgery. ...
